Abstract
The rapid advancements in Next-generation Sequencing (NGS) technologies have fundamentally transformed genomic research, broadening its application across diverse scientific domains including healthcare, agriculture, and environmental sciences. This manuscript provides a comprehensive overview of the current state and future potential of NGS technologies, emphasizing their role in driving innovative solutions and addressing complex biological questions. The integration of NGS with computational genomics and artificial intelligence has notably enhanced the speed and accuracy of genetic analyses, facilitating the emergence of precision medicine and personalized healthcare solutions. Technological innovations such as single-molecule and long-read sequencing techniques have overcome previous limitations of NGS, enabling more detailed and accurate genetic profiling and discovery. Furthermore, the manuscript discusses the democratization of genomic research facilitated by reduced costs and the miniaturization of sequencing technologies, which have expanded access and application worldwide. Ethical, legal, and social implications, particularly concerning data privacy and equitable access, are also critically examined to ensure responsible usage and broad benefit from genomic advances. By highlighting both achievements and ongoing challenges, the manuscript underscores the transformative impact of genomic technologies on science and society, heralding a new era of medical and biological research.
Keywords:
Next-Generation sequencing, NGS, computational genomics, precision medicine, artificial intelligence, ethical implications, technological innovationsReferences
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Copyright (c) 2025 Prasanna Srinivasan Ramalingam, Rajashekar Rao Barkur, Manjisa Choudhury, Priyanka Singla, Pavan Kumar, Prabhat, Ranjit Sah
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