Abstract

Background: Type 2 diabetes, or non-insulin-dependent diabetes mellitus, is a well-known medical condition that increasingly affects the young generation. This paper looks at the role of genetic and ethnic background on food choices and obesity, among UK's Generation Z and their predisposition to T2D.

Methods: This study aimed to determine the dietary patterns, body weight indices, and T2D status of Generation Z people from diverse ethnic backgrounds. Self-administered questionnaires and medical records were used to assess the subjects' genetic and ethnic-culinary backgrounds.

Results: The study shows that genetic and ethnic factors have a strong relation to diet and weight gain, which in turn increases the probability of T2D. Hence, South Asians and Africans exhibited higher T2D prevalence attributable to their high-carbohydrate diets and insulin-resistance genes. Unhealthy foods and their unhealthy patterns were linked with obesity and high T2D risk mainly owing to the consumption of processed foods and high sugar. Such a situation with T2D if left uncontrolled, particularly in youths will result in long-term disastrous complications such as cardiovascular diseases, renal failure, and cognitive dysfunction.

Conclusion: The intervention for T2D using live modalities and other public health strategies is necessary for preventing complication-related ailments. The recommendations consequently adopt health promotion activities such as healthy nutrition, routine check-ups on health, and appropriate public health interventions that are culturally competent.

Keywords:

Next-Generation sequencing, NGS, computational genomics, precision medicine, artificial intelligence, ethical implications, technological innovations

References

[1]. Rahman S, Majumder MdAA, Kabir R, Haque M, Gupta S, Arafat SMY, et al. Cardiovascular Disease and Diabetes: Two Sides of the Same Coin! Recent Trends in Cardiovascular Risks,. InTech;. 2017.

[2]. Huang M-F, Courtney M, Edwards H, McDowell J. Factors that affect health outcomes in adults with type 2 diabetes: A cross-sectional study. Int J Nurs Stud. 2010;47:542–9.

[3]. Fogarty H, Gaul A, Syed S, Aleksejenko N, Geoghegan R, Conroy H, et al. Adherence to hydroxyurea, health-related quality of life domains and attitudes towards a smartphone app among Irish adolescents and young adults with sickle cell disease. Irish Journal of Medical Science. (1971 -) 2022;191:809–16.

[4]. Vasishta S, Ganesh K, Umakanth S, Joshi MB. Ethnic disparities attributed to the manifestation in and response to type 2 diabetes: insights from metabolomics. Metabolomics. 2022;18:45.

[5]. DeForest N, Majithia AR. Genetics of Type 2 Diabetes: Implications from Large-Scale Studies. Curr Diab Rep .2022;22:227–35.

[6]. Schnurr TM, Jakupović H, Carrasquilla GD, Ängquist L, Grarup N, Sørensen TIA, et al. Obesity, unfavourable lifestyle and genetic risk of type 2 diabetes: a case-cohort study. Diabetologia. 2020;63:1324–32.

[7]. Zhuang P, Liu X, Li Y, Wan X, Wu Y, Wu F, et al. Effect of Diet Quality and Genetic Predisposition on Hemoglobin A1c and Type 2 Diabetes Risk: Gene-Diet Interaction Analysis of 357,419 Individuals. Diabetes Care. 2021;44:2470–9.

[8]. Kyrou I, Tsigos C, Mavrogianni C, Cardon G, Van Stappen V, Latomme J, et al. Sociodemographic and lifestyle-related risk factors for identifying vulnerable groups for type 2 diabetes: a narrative review with emphasis on data from Europe. BMC Endocr Disord. 2020;20:134.

[9]. Diabetes UK. How many people in the UK have diabetes?. 2022.

[10]. Kramer H, Shoham D. The Millennial Physician and the Obesity Epidemic.Clin J Am Soc Nephrol. 2019;14:4–6.

[11]. Jyotsna F, Ahmed A, Kumar K, Kaur P, Chaudhary MH, Kumar S, et al. Exploring the Complex Connection Between Diabetes and Cardiovascular Disease: Analyzing Approaches to Mitigate Cardiovascular Risk in Patients With Diabetes. Cureus. 2023;15:e43882.

[12]. Alzamil H. Elevated Serum TNF-α Is Related to Obesity in Type 2 Diabetes Mellitus and Is Associated with Glycemic Control and Insulin Resistance. J Obes. 2020;2020:5076858.

[13]. Kabir R, Hayhoe R, Bai ACM, Vinnakota D, Sivasubramanian M, Afework S, et al. The systematic literature review process: a simple guide for public health and allied health students. Int J Res Med Sci .2023;11:3498–506.

[14]. Alradie-Mohamed A, Kabir R, Arafat SMY. Decision-Making Process in Female Genital Mutilation: A Systematic Review. Int J Environ Res Public Health. 2020;17.

[15] Kabir R, Syed HZ, Vinnakota D, Okello S, Isigi SS, Abdul Kareem SK, et al. Suicidal behaviour among the university students in the UK: A systematic review. Heliyon. 2024;10:e24069.

[16]. Ahmed A, Tsiami A, Khan HTA. Effects of dietary and lifestyle management on type 2 diabetes development among ethnic minority adults living in the UK: A generational shift. Int J Gastron Food Sci. 2023;31:100634.

[17]. Alae-Carew C, Green R, Stewart C, Cook B, Dangour AD, Scheelbeek PFD. The role of plant-based alternative foods in sustainable and healthy food systems: Consumption trends in the UK. Sci Total Environ. 2022;807:151041.

[18]. Priporas C-V, Vellore-Nagarajan D, Kamenidou I (Eirini). Stressful eating indulgence by generation Z: a cognitive conceptual framework of new age consumers’ obesity. Eur J Mark .2022;56:2978–3006.

[19]. Kaylor , Sara K, Allen , Isabel, Crim , Anna Dailey, Callihan , Michael L. Calories and control: Eating habits, behaviors, and motivations of Generation Z females. J Am Coll Health. 2023;71:2578–86.

[20]. Burns C, Francis N. Type 2 Diabetes: Etiology, Epidemiology, Pathogenesis, and Treatment Metabolic Syndrome, Cham .Springer International Publishing;. 2023, p 509–28.

[21]. Bjornstad P, Chao LC, Cree-Green M, Dart AB, King M, Looker HC, et al. Youth-onset type 2 diabetes mellitus: an urgent challenge. Nat Rev Nephrol. 2023;19:168–84.

[22]. Naaz S. Knowledge, attitude and practices pertaining to healthy lifestyle in prevention and control of chronic diseases: a rapid review. Int J Community Med Public Health. 2021;8:5106.

[23]. Narula S, Nigam S. Understanding and Analysing the Role of Knowledge, Attitude and Practices for Prevention of Diabetes Sustainable Business Practices for Rural Development, Singapore. Springer Singapore;. 2020, p 41–67.

[24]. Sidhu T, Lemetyinen H, Edge D. ‘Diabetes doesn’t matter as long as we’re keeping traditions alive’: a qualitative study exploring the knowledge and awareness of Type 2 diabetes and related risk factors amongst the young Punjabi Sikh population in the UK. Ethn Health. 2022;27:781–99.

[25]. Sun C, Kovacs P, Guiu-Jurado E. Genetics of Body Fat Distribution: Comparative Analyses in Populations with European, Asian and African Ancestries. Genes (Basel). 2021;12.

[26]. Lane MM, Gamage E, Travica N, Dissanayaka T, Ashtree DN, Gauci S, et al. Ultra-Processed Food Consumption and Mental Health: A Systematic Review and Meta-Analysis of Observational Studies. Nutrients. 2022;14:2568.

[27]. Tahir NS, Ahmad Y, Bustami MR, Abd Hamid SNF, Muhammad Zamri NEM, Mulyany R. Understanding the Perception of Generation Z towards Fast Food’s Product Safety, Nutrition, and Health. Asian Journal of Environment-Behaviour Studies .2023;8:63–81.

[28]. Lustig RH. Ultraprocessed Food: Addictive, Toxic, and Ready for Regulation. Nutrients. 2020;12:3401.

[29]. Abbasi A, Juszczyk D, van Jaarsveld CHM, Gulliford MC. Body Mass Index and Incident Type 1 and Type 2 Diabetes in Children and Young Adults: A Retrospective Cohort Study. J Endocr Soc .2017;1:524–37.

[30]. Hwalla N, Jaafar Z, Sawaya S. Dietary Management of Type 2 Diabetes in the MENA Region: A Review of the Evidence. Nutrients .2021;13:1060.

[31]. Inaishi J, Saisho Y. Beta-Cell Mass in Obesity and Type 2 Diabetes, and Its Relation to Pancreas Fat: A Mini-Review. Nutrients. 2020;12:3846.

[32]. Korac B, Kalezic A, Pekovic-Vaughan V, Korac A, Jankovic A. Redox changes in obesity, metabolic syndrome, and diabetes. Redox Biol. 2021;42:101887.

[33]. Khin PP, Lee JH, Jun H-S. Pancreatic Beta-cell Dysfunction in Type 2 Diabetes. Eur J Inflamm. 2023;21.

[34]. Makowska M, Boguszewski R, Hrehorowicz A. Generational Differences in Food Choices and Consumer Behaviors in the Context of Sustainable Development. Foods. 2024;13:521.

[35]. Henney AE, Gillespie CS, Alam U, Hydes TJ, Boyland E, Cuthbertson DJ. Ultra‐processed food and non‐communicable diseases in the United Kingdom: A narrative review and thematic synthesis of literature. Obesity Reviews. 2024;25.

[36]. Lee H-J, Choi E-K, Han K-D, Kim DH, Lee E, Lee S-R, et al. High variability in bodyweight is associated with an increased risk of atrial fibrillation in patients with type 2 diabetes mellitus: a nationwide cohort study. Cardiovasc Diabetol. 2020;19:78.

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How to Cite

Kiran, A., Davod, A., Cortnage, M., Hayhoe, R., & Kabir, R. (2025). Risk factors associated with the onset of type 2 diabetes in Generation Z in the United Kingdom. Evidence Public Health, 1(1). Retrieved from http://eph.evidencejournals.com/index.php/j/article/view/11
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